The human YB-1 protein plays multiple cellular roles, of which many are dictated by its binding to RNA and DNA through its Cold Shock Domain (CSD).Using molecular dynamics simulation approaches validated by experimental assays, the YB1 CSD was found to interact with nucleic acids in kaimana youth services a sequence-dependent manner and with a high
Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor.UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decrea
The operational reliability and high efficiency of modern electrical machines depend on the ability to transfer heat in the construction parts of the machine.Therefore, many authors study various thermal models and work on the development of effective heat dissipation.New insights and methods lead to improved techniques for the thermal design of el
Artificial organelles, molecular factories and nanoreactors are membrane-bound systems envisaged to exhibit cell-like functionality.These constitute liposomes, polymersomes or hybrid lipo-polymersomes that display different membrane-spanning channels and/or enclose molecular modules.To achieve more complex functionality, an artificial organelle sho